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NAD + -dependent signaling reactions, unlike NAD(P) + : NAD(P)H redox reactions, where the dinucleotide is not catabolized, do break apart the NAD + molecule, producing nicotinamide (NAM) as a byproduct (figure 4).[15] Because of this, they are often described as NAD + -consuming reactions (i.e., they consume the NAD + molecule)