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To further our understanding of the DDR, we performed a series of genome-scale loss-of-function CRISPR interference (CRISPRi) screens to map the cellular response to DDRi targeting core DDR proteins: PARP, ATR, ATM, DNAPK, and WEE1
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The research landscape shows convergent epigenetic phenotypes across immune-mediated conditions, for example, synovial and T-cell hypomethylation in rheumatoid arthritis (RA), interferon-driven signatures in systemic lupus erythematosus (SLE), mucosal (and saliva-detectable) alterations in celiac disease (CeD) and therapy-responsive methylomes in multiple sclerosis (MS) (2,3,13,14)