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It is created by a consortium of endothelial, nerve, and smooth muscle cells forming the walls of the capillaries supplying the brain, and it thus covers a huge surface area for exchange “across”, “in”, or “into” the brain—estimated to be between 12 and 18 m 2 in adults [27]
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The satellite cell activation is particularly important—these muscle stem cells normally remain quiescent but can be recruited by IGF-1 signaling to fuse with existing fibers, adding nuclei that support increased fiber size
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