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78 A phase II clinical trial that combined a methionine-free diet with cystemustine in patients with metastatic melanoma and glioma revealed a decline in the activity of MGMT , a protein that helps tumors resist chemotherapy, and varied patient responses, including long-term disease stabilization [Table 2]

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Therefore, the use of a crossing BBB peptide (CBBBP), such as GGGGYGRKKRRQRRR, has garnered considerable attention in the scientific community for its ability to facilitate the delivery of therapeutic targets (Becker et al., 2004)