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Although their largest involvement is in nutrient and metabolic regulation, around 10% of them might cross the BBB, as shown in animal studies with mechanistic details (Monteiro-Cardoso et al., 2021)

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Interestingly, murine studies have shown that intestinal overexpression of ACE2 is associated with increased abundance of anti-inflammatory microbial species, in contrast to ACE2 knockout models, which exhibit more proinflammatory profiles [86]