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[229], in mammals, methylglyoxal arises in 0.05–0.1% as a minor product from (a) glyceraldehyde-3-phosphate and dihydroxyacetone phosphate degradation in glycolysis, (b) oxidation of acetone by cytochrome P450, (c) oxidation of aminoacetone by semicarbazide amine oxidase, and (d) degradation of glycated proteins and monosaccharides

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And let me be clear: this isn’t necessarily just a matter of some people “eating through” the medication