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As GSH to GSSG ratio largely determines the intracellular redox potential (proportional to the log of [GSH] 2 /[GSSG]) [5], to prevent a major shift in the redox equilibrium when oxidative stress overcomes the ability of the cell to reduce GSSG to GSH, GSSG can be actively exported out of the cell or react with a protein sulfhydryl group leading to the formation of a mixed disulfide

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