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The gene for the first enzyme of the pathway, phosphoglycerate dehydrogenase ( PHGDH ), has been shown to be focally amplified in some triple-negative breast cancers and melanomas [58,59]

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In comparison with the miRNA control, the mRNA and protein levels of IGF-1 were upregulated when miR-483-3p was knocked down with anti-miR-483-3p in human dNK cells (Fig